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Recombinant Rabbit antibody (2019-nCoV) Spike Neutralizing Antibody, Rabbit Antibody
Background
The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.
| Name |
Recombinant Rabbit antibody (2019-nCoV) Spike Neutralizing Antibody, Rabbit Antibody
| Application | Invitro research and manufacture use; ELISA assay, |
| Formulation | 0.2 μm filtered solution in PBS | Buffer: | 1X PBS buffer |
| Storage: | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative- Free. Avoid repeated freeze-thaw cycles. | Concentration | ELISA: 1:5000-1:10000 |
| Expiration Date: | 30 days refrigerated at -2-8ºC and twelve months frozen at -20 ºC or below from production date. To be evaluated independently | Feature | High Sensitivity and Specificity |
Specification Data
| Description: |
Recombinant Rabbit antibody (2019-nCoV) Spike Neutralizing Antibody, Rabbit Antibody
| |
| Source: | Rabbit IgG1 | |
| Immunogen: |
SARS-CoV-2 (2019-nCoV) Spike RBD Protein | |
| Formulation: |
Recombinant Rabbit antibody (2019-nCoV) Spike Neutralizing Antibody, Rabbit Antibody
| |
| Purification: | DEAE chromatography | |
| Concentration: | 1.0 mg/mL (OD280 nm, E0.1% = 1.40) | |
| Affinity Constant: | Not determined | |
| Buffer: | 0.015M potassium phosphate buffer, 0.85% NaCl, 0.05% NaN3 pH=7.2 | |
| Pairing Assays: | N/A | |
| Purity: | >95% by HPLC and SDS-PAGE | |
| Application: |
ELISA, WB
| |
Description of first aid measures
General information : No special measures required.
After inhalation :If inhaled, remove to fresh air.If not breathing give artificial respiration.Seek medical attention if needed.
After skin contact: In case of contact, wash skin with soap and copious amounts of water. Seek medical attention if needed.
After eye contact : In case of contact ,flush eyes with copious amounts of water for at least 15 minutes.Seek medical attention if needed.
After swallowing : If swallowed, wash out mouth with water provided person is conscious. Seek medical attention if needed.
Serial dilutions of Anti-SARS-CoV-2 Neutralizing Antibody (Catalog# 40592-R117) was detected by SARS-CoV-2 (2019-nCoV) Inhibitor Screening ELISA Kit. The IC50 is typically 0.5-5 nM.
The neutralization activity is Measured by microneutralization assay in vitro. The virus microneutralizaiton (MN) test was performed on 293T-ACE2 cells infected with SARS-CoV-2 (2019-nCoV) Spike Pseudovirus under treatment of serial dilutions of neutralizing antibody. The infection was neutralized by increasing concentrations of Anti-SARS-CoV-2 Neutralizing Antibody. Rate of inhibition was determined by comparing the Relative Light Unit (RLU) of Luciferase reporter in different antibody concentrations. The IC50 is typically 0.185 µg/mL.
FAQ
1. Q:Are you a factory or trading company?
A: We are a factory, we have rich experience for manufacturing Medical Device more than 10 years.
2.Q:Where is your factory located? How can i visit there?
A: Our factory is located in Jiaxing city, Zhejiang Province, China.
It is about more than 1 hours from Shanghai.
2. 3.Q:Can you make samples?
A: Yes, we can make samples for you.
4.Q:How does your factory do as quality control?
A: Quality is the lift of our factory. We have inspector in different post, and there are three inspectors before packing to get best quality products.
5.Q: How is your post market service ?
A: If any damaged rings in the course of carriage, with the checking it's our mistake, we will take full responsibility to compensate the customers.
6.Q:Can you do OEM for us?
A: Certainly. We also can build the moulding for our new customer.
7.Q:Does the price include freight?
A:No, please choose the express service provider or negotiate with us.